Matchup Summary

The upcoming Monday Night Football game features the San Francisco 49ers and Carolina Panthers. Both teams are looking to build on recent success; the 49ers (7-4) come off a decisive 41-22 win against Arizona last week, while the Panthers (6-5) prevailed over Atlanta in overtime, winning 30-27.

The 49ers will kick off at 8:15 PM ET at Levi’s Stadium in Santa Clara, California, and are currently favored by 7 points with an over/under of 49.5 points.

Key Player Updates

The 49ers welcome back several key players: quarterback Brock Purdy, wide receivers Ricky Pearsall and Jauan Jennings, tight end George Kittle, and tackle Trent Williams, all despite earlier injuries this season.

Fan Betting Information

Before betting on the 49ers vs. Panthers matchup, consider consulting the SportsLine projection model, which has had significant success in its NFL predictions.

Notable Bets:

• Spread: 49ers -7
• Over/Under: 49.5 points

For further details and the latest betting odds, be sure to check the expert picks on SportsLine!