Four games over Thanksgiving and Black Friday will limit the NFL DFS main slate on FanDuel and DraftKings, but there are still a lot of prominent players to consider for Sunday. Players like Josh Allen, Christian McCaffrey, Puka Nacua, and Trey McBride are potential high-scoring options for NFL DFS lineups. However, points may be hard to come by as weather could affect a few games and six matchups have an over/under of 41.5, with none exceeding 45.5.
How should these factors influence your NFL DFS choices this week, and who are the sleepers in the DFS player pool that can set your lineups apart? Before finalizing your NFL DFS choices or locking in lineups on platforms like DraftKings and FanDuel, make sure to check SportsLine’s advanced NFL DFS lineup optimizer.
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The DFS Optimizer employs data from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to pinpoint premier DFS picks for any slate on betting apps like DraftKings and FanDuel. It simulates each game 10,000 times to support DFS players in optimizing and constructing winning DraftKings and FanDuel lineups. Optimize, export, and confidently enter lineups with injury updates, player projections, and Vegas lines and picks, all using one powerful tool.
Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 13 schedule and just locked in its top daily fantasy football lineups. You can only see its optimal lineups at SportsLine.
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Top NFL Week 13 DFS picks for Sunday
One of the optimizer’s best DFS value picks for Sunday is Dolphins running back De’Von Achane ($8,700 on FanDuel, $8,300 on DraftKings), who faces the New Orleans Saints. He has excelled lately, accumulating an impressive 390 scrimmage yards in the last two weeks. With 21 carries in Week 12 and 22 carries in Week 11 — his two highest totals of the season — he has also been frequently targeted in the passing game. The Saints have allowed the ninth-most rushing yards to their opponents this season, making Achane a great value option this Sunday. See who else to pick here.
The optimizer’s NFL DFS strategy also includes focusing on Texans receiver Nico Collins at $6,700 on DraftKings and $8,100 on FanDuel. Last week, he had a quieter 3-55 receiving line on merely three targets. However, this is likely an outlier as he was targeted a total of 36 times over the last three games and recorded a 23-303-1 combined receiving line during that span. DFS competitors can confidently include him this Sunday against a Colts secondary that ranks 23rd in Fantasy points allowed to opposing receivers. You can see the remainder of the optimizer’s NFL DFS picks here.
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How to build Sunday Week 13 NFL DFS lineups
The NFL DFS Optimizer is also focusing on several undervalued players likely to have breakout performances on Sunday. These players could be game-changers in tournaments or cash games, deciding whether you win or leave empty-handed. You can only see who they are, and the rest of the optimizer’s NFL DFS picks, at SportsLine.
So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS selections present great value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and discover more.
