Highly notable rookie quarterback Shedeur Sanders will make his second start for the Cleveland Browns when they host the San Francisco 49ers in Week 13 of the NFL season. Sanders got the ball for Cleveland (3-8) in Week 12 and defeated the Las Vegas Raiders on the road, while defensive superstar Myles Garrett continued his march towards challenging the single-season sacks record. San Francisco (8-4) beat the Carolina Panthers on Monday Night Football.

Kickoff from Huntington Bank Field is set for 1 p.m. ET on CBS and Paramount+. The 49ers are 5.5-point favorites, according to the latest Browns vs. 49ers odds. The over/under for total points scored is 35.5, down seven from the opening line.

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Where to bet on Browns vs. 49ers

Odds: 49ers -5.5, over/under 35.5.

Cleveland is 3-8 outright but has managed to go 5-6 ATS and is 6-5 to the Over despite its strong defense. The Niners are 7-5 ATS and 7-5 to the Over. Both teams have gone Over in three of their last four games, and both have covered their last two games.

Click here to bet Browns vs. 49ers at FanDuel Sportsbook, where new users get $150 in bonus bets if their first bet of at least $5 wins.

Final Score Prediction: 49ers 23, Browns 21

For more Week 13 NFL picks, find all against the spread, total, and money-line picks for every game here.