The defending national champions, the Florida Gators, will clash with the highly ranked Duke Blue Devils during the 2025 ACC/SEC Challenge. This encounter will take place at Cameron Indoor Stadium in Durham, North Carolina, on Tuesday, with a scheduled tipoff at 7:30 p.m. ET. Currently ranked as No. 15, Florida comes into this game with a record of 5-2, while Duke boasts an impressive 8-0 record.

Both teams have historic ties within this challenge, with a balanced record of 1-1 since the matchup’s inception in 2023. The Blue Devils aim to capitalize on their home-court advantage–having established a favorable 5-2 record against the Gators historically. Duke is currently favored by 8.5 points, while the over/under total sits at 157.5 points.

Before placing any bets, enthusiasts are encouraged to review expert insights and simulation results from the SportsLine Projection Model, which has successfully simulated this game 10,000 times. Notably, the model has yielded substantial returns, generating over $2,000 in profits for $100 players on its top picks in college basketball over the last few seasons.

Key Matchup Information:

• Florida vs. Duke Spread: Duke -8.5 at DraftKings Sportsbook
• Total Points Over/Under: 157.5
• Moneyline: Duke -410, Florida +316

For those looking to view the match, it’s available to stream on Fubo TV (Try for free).

Follow the links for more detailed insights and predictions: See Picks at SportsLine.