A spot in the College Football Playoff bracket is on the line for the No. 17 Virginia Cavaliers when they meet the Duke Blue Devils in the 2025 ACC Championship Game on Saturday. The Cavaliers finished the regular season with a 10-2 record, including 7-1 in the ACC, and can secure an automatic CFP bid if they win against the Blue Devils.

Kickoff from Bank of America Stadium in Charlotte is set for 8 p.m. ET. The Cavaliers are entering as 4-point favorites, and the over/under is 57.5. Before placing bets on the Duke vs. Virginia matchup, explore college football predictions from the SportsLine Projection Model.

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Why Virginia Can Cover

The Cavaliers, with an 8-4 record against the spread this season, defeated Duke 34-17 on Nov. 15 as 5-point underdogs. Now, as slight favorites, they are eager to advance to the playoffs.

Virginia ranks second in the ACC for total defense and fourth in offense, positioning them well to control this game.

Why Duke Can Cover

Duke’s offense, which ranks second in the ACC for scoring, is spearheaded by quarterback Darian Mensah, who’ve thrown for 3,450 yards and 28 touchdowns this season. The Blue Devils also have a talented running back duo and outstanding receivers.

Making Picks

The model anticipates an under on the total points, revealing one side of the spread holding a 60% success rate. You can see the model’s predictions on SportsLine.