The Week 15 NFL slate features 16 games, some with playoff implications. A notable matchup is between the Buffalo Bills (9-4) and the New England Patriots (11-2), with Buffalo slightly favored by 1 point. Currently, Buffalo is on a winning streak of two games, while the Patriots have won 10 in a row.

Another significant game involves the Detroit Lions (8-5) versus the Los Angeles Rams (10-3), where the Lions are vying for a playoff spot while the Rams aim to hold on to the No. 1 seed in their conference. Historically, Detroit has secured victories in their last two encounters against the Rams, including a thrilling 26-20 overtime win in September 2024. The Rams enter as 5.5-point favorites at home.

The largest point spreads for Sunday include the Raiders versus the Eagles (-12.5), Titans against the 49ers (-12.5), and Jets meeting the Jaguars (-11.5).

Before placing bets or making predictions for Week 15, check out the predictions by the self-learning SportsLine AI for game odds and score forecasts.

SportsLine’s AI system processes historical data and evaluates each team’s performance to generate match predictions, helping bettors with informed decisions.