The Week 15 NFL schedule includes 16 games, some of which have significant implications for playoff scenarios. A prominent matchup features the Buffalo Bills (9-4) against the New England Patriots (11-2), with Buffalo favored by 1.5 points. As the Bills take on the Patriots, both teams are looking to solidify their playoff positions—Buffalo is currently on a two-game win streak, while New England has won their last 10 matches.

Another key contest is between Detroit Lions (8-5) and Los Angeles Rams (10-3), with the Rams entering as 5.5-point favorites at home. Notably, this week’s games also include significant spreads like Raiders vs. Eagles (-11.5), Titans vs. 49ers (-12.5), and Jets vs. Jaguars (-12.5). Before finalizing any Week 15 picks or score predictions, visit this link for AI-driven insights.

The AI from SportsLine utilizes cutting-edge techniques and continuously updates its predictions based on historical and recent data.

Top Week 15 NFL AI Picks: The AI predicts the Cowboys (currently -5.5) will comfortably cover against the Vikings, backed by quarterback Dak Prescott’s impressive stats of 3,637 yards and 26 touchdowns over 13 games.

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