The Week 15 NFL schedule has 16 games, highlighting several crucial matchups for the playoffs. Notably, the Buffalo Bills (9-4) will face the New England Patriots (11-2), with the Bills favored by 1.5 points. Josh Allen leads Buffalo, who is currently on a two-game winning streak, while New England aims to extend its 10-game winning streak with Drake Maye at the helm.

In another important NFC clash, the Detroit Lions (8-5) will challenge the Los Angeles Rams (10-3). The Rams enter this matchup as 5.5-point favorites and are looking to maintain the No. 1 seed in their conference amidst fierce competition.

For NFL bettors, SportsLine’s AI has thoroughly analyzed the odds and provided insights for all 15 games this week. The advanced predictions leverage data science and machine learning for accurate outcomes based on historical performance and matchup scores.

Key AI insights indicate that the Dallas Cowboys (-5.5) are likely to cover against the Minnesota Vikings, with Dak Prescott having a standout season. After completing 69% of his passes for over 3,600 yards and 26 touchdowns, Prescott is on a roll. Additionally, running back Javonte Williams has made significant contributions with over 1,000 rushing yards this season.

For the latest predictions, visit SportsLine.