The 2025 NFL regular season has turned into one of the most unpredictable in recent memory. As we head into Week 15, players like Patrick Mahomes, Lamar Jackson, and Joe Burrow find themselves on the playoff margins. Meanwhile, Josh Allen and the Buffalo Bills are close to ceding the AFC East title to the New England Patriots. In an unexpected twist, Philip Rivers is making a return to start for the Indianapolis Colts. Madness!
With the league completely turned on its head, predicting weekly outcomes has become quite a challenge. As we move closer to the end of the regular season, the stakes have never been higher, with playoff spots on the line. For example, New England can secure the AFC East with a win over Buffalo at Gillette Stadium, while the Los Angeles Rams and Denver Broncos can clinch playoff berths with victories.
Amid these intriguing storylines, it’s crucial to finalize our betting strategies. Below are the best bets for Week 15, along with predictions for each match.
Baltimore Ravens at Cincinnati Bengals
- Date and Time: Sunday, 1 p.m. ET (CBS | Paramount+)
Lamar Jackson holds a 10-2 career record against the Bengals, including a 6-2 mark against Joe Burrow. On the surface, this record might give bettors confidence in Baltimore. However, Jackson hasn’t looked like his usual self lately, particularly after a disappointing performance against Pittsburgh, where he completed only 54.3% of his passes.
With the Ravens failing to cover in four consecutive games prior to Week 15, they are not a reliable bet at 4-9 against the spread for the season.
Projected Score: Bengals 27, Ravens 24
Pick: Bengals +2.5
Green Bay Packers at Denver Broncos
- Date and Time: Sunday, 4:25 p.m. ET (CBS | Paramount+)
The Broncos are likely to face skepticism after a disheartening last-minute loss last week against the Raiders. Yet the Packers are coming off a last-second win over the Chicago Bears, which has rejuvenated their position in the NFC North. However, the Packers have a history of faltering at crucial moments, especially on the road against top defenses.
Projected Score: Broncos 23, Packers 21
Pick: Broncos +2.5
Indianapolis Colts at Seattle Seahawks
- Date and Time: Sunday, 4:25 p.m. ET (CBS | Paramount+)
The return of Philip Rivers is a captivating storyline. After a long absence from meaningful play, Rivers is poised to start for the Colts. However, facing a Seattle defense that excels in points and play allowed will be a massive challenge for him.
Projected Score: Seahawks 30, Colts 16
Pick: Seahawks -13.5
Minnesota Vikings at Dallas Cowboys
- Date and Time: Sunday, 8:20 p.m. ET (NBC | Fubo, try for free)
J.J. McCarthy has shown promise following his performance against Washington. However, the jury is still out, and Dallas can be expected to rebound from previous setbacks.
Projected Score: Cowboys 30, Vikings 17
Pick: Cowboys -5.5
Miami Dolphins at Pittsburgh Steelers
- Date and Time: Monday, 8:15 p.m. ET (ABC, ESPN | Fubo, try for free)
The Dolphins are in excellent form, enjoying a four-game winning streak after a shaky start to the season. With defensive stats leading the league, they could perform well against a less stable Steelers team.
Projected Score: Steelers 23, Dolphins 21
Pick: Dolphins +3
Additional Matchups
- Cardinals at Texans: Projected Score: Texans 30, Cardinals 21. Pick: Cardinals +9.5
- Bills at Patriots: Projected Score: Patriots 27, Bills 24. Pick: Patriots +1.5
- Browns at Bears: Projected Score: Bears 24, Browns 16. Pick: Bears -7.5
- Chargers at Chiefs: Projected Score: Chargers 24, Chiefs 21. Pick: Chargers +6
- Raiders at Eagles: Projected Score: Eagles 30, Raiders 17. Pick: Raiders +12.5
- Jets at Jaguars: Projected Score: Jaguars 30, Jets 20. Pick: Jets +13.5
- Commanders at Giants: Projected Score: Giants 24, Commanders 21. Pick: Giants -2.5
- Panthers at Saints: Projected Score: Panthers 24, Saints 20. Pick: Panthers -2.5
- Lions at Rams: Projected Score: Rams 30, Lions 27. Pick: Lions +6
- Titans at 49ers: Projected Score: 49ers 33, Titans 17. Pick: 49ers -12.5
