The Week 16 NFL schedule highlights several teams concluding their regular season at home, with notable betting trends. For instance, the Ravens will face the Patriots as -2.5 favorites, while the Cardinals host the Falcons at +2.5. Notably, both teams have struggled with losses against the spread, suggesting they may be risky picks this week.

Recent data reveals a higher number of road favorites than home teams giving points. Among the intriguing matchups, the Giants are +3 against the Vikings, the Panthers face the Bucs also at +3, and the Titans sit at +3.5 against the Chiefs, who will be missing Patrick Mahomes due to injury.

This week’s predictions indicate a strong likelihood of the Ravens covering against New England, propelled by a recent strong performance, while the Chiefs are expected to outperform the Titans despite the shift in betting lines after Mahomes’ injury. For comprehensive betting insights and odds, refer to the detailed analysis at SportsLine.