
The NFL Week 17 schedule presents a full lineup, including three games on Christmas Day, two on Saturday, and ten on Sunday. Key matchups include the Seattle Seahawks, leading the NFC West, against the Carolina Panthers, with Seattle favored by 7 points via DraftKings Sportsbook. The Jacksonville Jaguars, leading the AFC South, will face the Indianapolis Colts with a prediction favoring the Jaguars by 6.5 points.
Sunday showcases the largest spread with the Patriots at -13.5 against the Jets and the Rams at -8 versus the Falcons on Monday Night Football. The smallest spreads include the Giants versus Raiders (+1.5), Saints (-2.5) against Titans, Eagles facing the Bills (-1), and Bears versus 49ers (-3).
Seattle is positioned as the NFC’s top seed, while the Denver Broncos currently lead the AFC. Before laying any wagers on Week 17, it’s crucial to check the NFL odds and predictions provided by SportsLine AI.
Built on advanced AI and machine learning, SportsLine’s AI makes predictions by analyzing each team’s historical data and evaluating their defensive matchups with a score from 0 to 100. This system is frequently updated with new data, revealing significant betting line discrepancies. SportsLine’s AI has successfully recommended over 2,000 4.5- and 5-star picks since the 2023 season began.
For Week 17 betting, SportsLine AI has analyzed the odds and generated selections for all 16 games. You can view the AI predictions for the Week 17 NFL schedule here.
Top Week 17 NFL AI Picks
The AI predicts that the Steelers (-3, 33.5), currently on a three-game winning streak, will comfortably defeat the Browns. Pittsburgh has scored over in two of their last three games, and six of the last ten Browns games have also gone over.
Bet on the Over 34.5 via the DraftKings promo code, attracting $200 in bonus bets if your first wager wins. Pittsburgh aims for its first AFC North title since 2020, expecting to defeat Cleveland for a third consecutive time. SportsLine AI rates the Steelers as an A+ pick, predicting an average score of 24-15.
Discover further Week 17 predictions and bets at SportsLine.{“predictions_note”:“Visit SportsLine now to uncover the best picks across the spread, over-under, and money line options, all from the SportsLine AI that has maintained a high success rate this season.”}


