The Virginia Cavaliers will take on the Louisville Cardinals on January 13, 2026, in what promises to be an exciting college basketball clash as both teams face off in their fifth game of the ACC season. Virginia, currently ranked No. 16 with a record of 14-2 and 3-1 in conference play, seeks to extend its three-game winning streak following a decisive 70-55 victory over Stanford. Conversely, the No. 20 ranked Louisville (12-4, 2-2 ACC) is looking to build on its recent victory over Boston College, winning 75-62 on January 10.

Tip-off is set for 7 p.m. ET at the KFC Yum! Center in Louisville, Kentucky. The latest betting odds favor Louisville by 3.5 points, with an over/under set at 154.5, increasing two points from the opening line. Before making your bets on the Virginia vs. Louisville matchup, be sure to check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model. You can target the DraftKings promo code for $300 in bonus bets with a qualifying deposit.

According to the SportsLine Projection Model, the total points predicted for this game is 152, reflecting an under hit in 54% of simulations. Given both teams’ recent performances and overall statistics, expectations for a low-scoring game could hold true; historically, the last ten matchups between these teams recorded an average of just 124.8 points.

To access detailed betting insights, including which side of the spread might yield better odds, head to SportsLine now for exclusive picks derived from 10,000 simulations.