The UConn Huskies enter the 2025 March Madness bracket as back-to-back defending champions. They struggled this season, finishing with a 23-10 record and gaining a No. 8 seed in the tournament, opening against No. 9 Oklahoma. If they win, they could face top-seeded Florida in the West Region.

Can UConn wreak havoc and make a deep run in the 2025 NCAA Tournament, or will teams like Florida, St. John’s, Texas Tech, or Kansas represent the West in the Final Four? Before filling out your NCAA Tournament bracket for 2025, be sure to see the 2025 March Madness bracket picks from the proven computer model at SportsLine.

SportsLine’s model has simulated every game of the tournament 10,000 times, achieving a strong track record in recent years. It accurately predicted UConn’s championship run last year while identifying 13 teams that reached the Sweet 16 and nailed Alabama’s run to the Final Four.

It has also spot-on identified numerous first-round upsets, having predicted 24 by double-digit seeds since its inception.

As the optimal NCAA Tournament 2025 bracket is revealed, the model’s predictions about matchups are already available.

Top 2025 March Madness bracket picks

• The model predicts No. 2 seed Tennessee will defeat Kentucky in the Sweet 16 despite having lost to them twice this year. The Wildcats are grappling with injuries to key players, which could hinder their chances.
• No. 10 Utah State is projected to upset No. 7 UCLA in the Midwest’s first round. Utah started strong this season at 16-1, ultimately finishing at 26-7. Their effective field goal percentage of .567 ranks them 12th in the nation.

For insights into which teams might spring surprises and what the optimal strategies would be, check out SportsLine’s full predictions here.