2025 NCAA Tournament Betting Odds and Game Lines for March Madness

The opening odds and game spreads for the 2025 NCAA Tournament are available as teams gear up for March Madness. The initial betting lines reflect the tournament matchups set to kick off, including a notable appearance from the controversial pick, North Carolina, facing San Diego State in the First Four.

First Four

• No. 16 Alabama State (-3.5) vs. No. 16 Saint Francis
• No. 11 North Carolina (-3.5) vs. No. 11 San Diego State
• No. 16 American (-3.5) vs. No. 16 Mount Saint Mary’s
• No. 11 Xavier (-2.5) vs. No. 11 Texas

South Region

• No. 8 Louisville (-2.5) vs. No. 9 Creighton
• No. 4 Texas A&M (-7.5) vs. No. 13 Yale
• No. 5 Michigan (-2.5) vs. No. 12 UC San Diego
• No. 7 Marquette (-3.5) vs. No. 10 New Mexico
• No. 3 Iowa State (-13.5) vs. No. 14 Lipscomb
• No. 2 Michigan State (-18.5) vs. No. 15 Bryant

East Region

• No. 6 BYU (-3.5) vs. No. 11 VCU
• No. 3 Wisconsin (-16.5) vs. No. 14 Montana
• No. 8 Mississippi State (+1.5) vs. No. 9 Baylor
• No. 2 Alabama (-22.5) vs. No. 15 Robert Morris
• No. 5 Oregon (-5.5) vs. No. 12 Liberty
• No. 7 Saint Mary’s (-4.5) vs. No. 12 Vanderbilt
• No. 4 Arizona (-13.5) vs. No. 13 Akron

Midwest Region

• No. 7 UCLA (-5.5) vs. No. 10 Utah State
• No. 8 Gonzaga (-6.5) vs. No. 9 Georgia
• No. 2 Tennessee (-19.5) vs. No. 15 Wofford
• No. 4 Purdue (-9.5) vs. No. 13 High Point
• No. 5 Clemson (-7.5) vs. No. 12 McNeese
• No. 1 Houston (-28.5) vs. No. 16 SIU-Edwardsville
• No. 3 Kentucky (-10.5) vs. No. 14 Troy

West Region

• No. 7 Kansas (-5.5) vs. No. 10 Arkansas
• No. 3 Texas Tech (-15.5) vs. No. 14 UNC Wilmington
• No. 2 St. John’s (-17.5) vs. Omaha
• No. 6 Missouri (-6.5) vs. No. 11 Drake
• No. 4 Maryland (-11.5) vs. No. 13 Grand Canyon
• No. 5 Memphis (+2.5) vs. No. 12 Colorado State
• No. 1 Florida (-28.5) vs. No. 16 Norfolk State

No. 8 UConn (-3.5) vs. No. 9 Oklahoma.