The final two spots in the 64-team bracket will be on the line Wednesday night in Dayton, Ohio, as the second night of the First Four will solidify the matchups for the First Round of the 2025 NCAA Tournament. These are the games that get the appetite going for Thursday and Friday’s main course, where we will enjoy wall-to-wall March Madness action from midday into the deep evening hours.

Wednesday’s First Four games will begin with a battle of No. 16 seeds in the East Region as Patriot League champion American takes on MAAC champion Mount St. Mary’s. It’s a great opportunity for both teams to show out on a big stage and hopefully extend their NCAA Tournament stay, even if winning results in the ‘honor’ of playing Duke on Friday afternoon in Raleigh, North Carolina.

Then, in the night cap, we will see two of the last teams into the field with No. 11 seed Texas and No. 11 seed Xavier going head-to-head in Midwest Region action. Both teams had ups and downs through the year that resulted in getting pushed to the edge of the field and having to play in the First Four – like the Longhorns’ 12 losses in conference play and Xavier having just one Quad 1 win.

Pick: Mount St. Mary’s +2.5

Pick: Xavier -2.5
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