Under the leadership of head coach Kelvin Sampson, the Houston Cougars are now a top-tier NCAA basketball program. With a stellar 30-4 record and a No. 1 seed in the Midwest Region for the 2025 NCAA Tournament, they aim for their first national championship. However, they face tough competition from teams like Tennessee, Kentucky, and Purdue, who could derail their journey.

Last year, SportsLine’s computer simulation accurately predicted major upsets, such as No. 11 Oregon defeating No. 6 South Carolina. The model has a proven history of identifying surprise outcomes, making it a reliable resource going into this year’s tournament. For detailed predictions, you can refer to this link.

Key Upset Predictions

One intriguing prediction from the model is that First Four victor North Carolina will upset No. 6 Ole Miss in the first round, despite Ole Miss’s higher seeding. Conversely, No. 13 Yale is expected to defeat No. 4 Texas A&M, a team struggling with recent performance.

How to make informed predictions for the 2025 NCAA Tournament? With so many potential upsets, it’s crucial to consider all angles before finalizing your bracket. Don’t miss the expert analysis provided by SportsLine’s simulation models, which have effectively predicted bracket-busting outcomes in the past.