We’ve reached the Sweet 16 in the 2025 NCAA Tournament, featuring a significant matchup between No. 1 seed Florida and No. 4 seed Maryland in San Francisco. Both teams are navigating their quest to break a lengthy absence from the Final Four; Florida last reached the national semifinals in 2014 while Maryland seeks to add to its 2002 title. The Gators stand at 32-4 after victories over Norfolk State and UConn, while the Terrapins, at 27-8, progressed past Grand Canyon and Colorado State.

Game Details:

• Date & Time: Thursday, at 7:39 PM ET
• Location: Chase Center, San Francisco
• Spread: Florida -6.5
• Over/Under: 156.5 points

Experts suggest considering the picks from college basketball analyst Thomas Casale, who boasts an impressive 60-36 record on NCAA picks. Florida’s recent successes, including their pivotal guards who excelled against UConn, coupled with Maryland’s notable performances, particularly by freshman Derik Queen, set the stage for a thrilling game.

Betting Insights:

• Florida has covered the spread in 12 of its last 15 games.
• Maryland is 4-1 against the spread as an underdog in recent matches.

For comprehensive insights and predictions, including the X-factor that may tip the scales, visit SportsLine to stay ahead in March Madness.