The No. 1 seed Duke Blue Devils face off against the No. 4 seed Arizona Wildcats in the Sweet 16 of the 2025 NCAA Tournament on Friday. Duke enters this game on a 13-game winning streak, with a decisive victory over Baylor in the second round (89-66). They’ve won their tournament games by at least 23 points. Meanwhile, Arizona narrowly defeated Oregon 87-83.

In their previous encounter on November 22, Duke bested Arizona 69-55. Duke’s Maliq Brown is day-to-day, with head coach Jon Scheyer noting he might be fit to play against Arizona.

Game Details:

• Time: 9:39 p.m. ET
• Spread: Duke -9.5
• Over/Under: 154.5 points.

Duke’s Cooper Flagg, a candidate for the 2025 NBA Draft, leads with 18.7 points per game, making substantial contributions in rebounds and assists. Tyrese Proctor, another key player, averages 12.5 points and has shone in clutch moments. On the Arizona side, Caleb Love stands out as a strong player, leading his team with an average of 16.8 points per game.

Check out SportsLine for detailed insights and betting odds as this matchup approaches.