The Midwest Region title and a place in the Final Four will be contested when the second-seeded Tennessee Volunteers meet the top-seeded Houston Cougars in the Elite Eight of the 2025 NCAA Tournament.

Tennessee advanced with a 78-65 victory over Kentucky, while Houston narrowly beat Purdue 62-60 in the Sweet 16.

Game Details Tipoff is scheduled for 2:20 p.m. ET from Lucas Oil Stadium in Indianapolis, where Tennessee holds a 3-2 advantage in their all-time matchups. Their last meeting occurred in 1995, where Tennessee triumphed with a score of 69-49.

Houston is currently favored by 2.5 points in the latest odds, with an over/under set at 126.5 points.

Why Houston Can Cover

Senior guard L.J. Cryer seeks to regain his scoring touch after being limited to five points in the previous game against Purdue. He’s averaged 15.3 points per game this season.

Junior guard Emanuel Sharp has also been critical for Houston, averaging 12.6 points and contributing significantly in recent matchups.

Why Tennessee Can Cover

Tennessee’s senior guard Chaz Lanier, who leads the SEC in three-point shooting, has been explosive in prior games, including a stellar performance against UCLA.

Also notable is Zakai Zeigler, the SEC assists record holder, who delivered a double-double in the latest victory over Kentucky.

How to Make Houston vs. Tennessee Picks SportsLine’s model favors the over, predicting a total of 136 points scored collectively. Furthermore, a particular side of the spread has consistently exceeded 50% success.

For full predictions and insights, visit SportsLine for detailed analysis of the game.