One of the most anticipated matchups thus far in the 2025 Women’s NCAA Tournament takes place on Monday when the No. 2 seed UConn Huskies take on the No. 1 seed USC Trojans in the Elite Eight. The winner will advance to the Final Four in Tampa, Fla. The Huskies are riding a 13-game winning streak following wins over Arkansas State, South Dakota State, and Oklahoma in the Women’s NCAA bracket play. The Trojans, meanwhile, are averaging 78 points per game in the NCAA Women’s Tournament but will be without superstar JuJu Watkins, who suffered a torn ACL in USC’s win over Mississippi State in the second round.

Tipoff is 9 p.m. ET at Spokane Veterans Memorial Arena in Spokane, Washington. The latest UConn vs. USC odds list the Huskies as 12.5-point favorites, while the over/under is 140.5. Before making any USC vs. UConn picks, be sure to see the 2025 Women’s NCAA Tournament picks from SportsLine experts Aaron Barzilai and Calvin Wetzel.

Wetzel said, “UConn is looking to move to 4-0 against the spread in the NCAA Tournament and 8-0 in March. Until someone covers against them, it doesn’t make sense to overthink it.” They concluded that UConn is favored to cover the spread.

The Trojans had a tough time generating offense without Watkins, impacting their defensive strategy against UConn, which has performed excellently defensively in the tournament.