The Tuesday NBA schedule features a high-profile Eastern Conference matchup between the Cleveland Cavaliers and New York Knicks. Cleveland is 60-15 overall and 32-5 at home, while New York is 48-27 overall and 22-15 on the road. The Knicks are looking to stay hot and win their fourth straight game after they defeated the Philadelphia 76ers 105-91 on Tuesday. The Cavs, who have the best record in the East, have won four of their last five after beating the Los Angeles Clippers 127-122 on Sunday.

Tipoff from Rocket Arena in Cleveland is set for 7 p.m. ET. The Cavs are 10.5-point favorites in the latest Knicks vs. Cavaliers odds from SportsLine consensus, while the over/under for total points scored is 230.5. The Cavs are at -495 on the money line (risk $495 to win $100), while New York is at +375 (risk $100 to win $375).

Before making any Knicks vs. Cavs picks, be sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 24 of the 2024-25 NBA season on a sizzling 155-115 roll on all top-rated NBA picks dating back to last season.

Why the Cavaliers can cover

The Cavs have legitimate championship aspirations this season. Cleveland currently holds a 4-game lead over the Boston Celtics for the top spot in the Eastern Conference playoff picture. The Cavs have also performed well versus the number this season, going 44-30-1 against the spread.

The Cavs are led by the dynamic backcourt duo of Donovan Mitchell and Darius Garland. Mitchell averages a team-high 24.0 points per game to go with 4.9 assists and 4.5 rebounds. Garland is averaging 20.6 points and 6.7 assists per game.

Why the Knicks can cover

The Knicks are one of the hottest teams in the Eastern Conference, and look to be headed towards locking up the No. 3 seed in the playoff bracket. New York has won three straight games, and five of its last six.

Karl-Anthony Towns continues to shine for New York while Josh Hart also performs at a high level for the team.

How to make Cavs vs. Knicks picks

SportsLine’s model has simulated Knicks vs. Cavs 10,000 times and is leaning Under on the total, projecting 228 combined points. The model also says one side of the spread hits in well over 50% of computer simulations.

Visit SportsLine now to see which side of the Knicks vs. Cavaliers spread to back, and find out.