The 2025 Final Four will showcase a thrilling clash between the top-ranked Duke Blue Devils (35-3) and the equally strong Houston Cougars (34-4). With Duke leading the nation in offensive stats and Houston boasting the best defense, this rematch is hotly anticipated. Last year’s Sweet 16 saw Duke taking the victory, and they are now vying for their first championship game since 2015, while Houston seeks its first title game appearance since 1984.

Game Details

• Tip-off: 8:49 PM ET, CBS, Alamodome, San Antonio
• Duke is favored by 5.5 points with the total points set at 136.5.

Before placing your bets, make sure to check the predictions from SportsLine’s expert Micah Roberts. Over the past three seasons, he has an impressive record of 267-227, returning $1,578 to $100 bettors. Currently, he’s riding a 16-5-1 streak on Houston-related picks.

Betting Breakdown

• Duke vs. Houston spread: Duke -5.5
• Over/under: 136.5 points
• Money line: Duke -271, Houston +220

Insights on Duke

Duke tops the 2025 March Madness teams in scoring with an average of 91.8 points per game. They have scored at least 85 points in every tournament match leading to this Final Four. Their star player, Cooper Flagg, who is projected to be the top overall pick in the upcoming NBA draft, is averaging 18.9 points per game.

Insights on Houston

Conversely, Houston brings a 17-game win streak to this matchup and is recognized for its remarkable defense, allowing an average of just 56.5 points per game during the tournament. They feature a top-10 offense while efficiently executing plays to limit turnovers.

For those eager to explore further predictions and betting options, visit SportsLine for comprehensive insights.