The St. Louis Cardinals take on the Boston Red Sox in a significant early-season interleague game on Sunday Night Baseball. This meeting is the second of a doubleheader after the prior game was postponed due to rain. The Cardinals (4-3), who finished in second place in the National League Central last year with an 83-79 record, will put righthander Miles Mikolas (0-0, 3.38 ERA) to the test. Meanwhile, the Red Sox (4-4), who ended last season third in the AL East with a record of 81-81, are set to feature righthander Richard Fitts (0-1, 4.50 ERA).
First Pitch: 7:10 PM ET at Fenway Park in Boston. Current betting odds from Caesars Sportsbook indicate Boston as the -124 favorite (risk $124 to win $100), with the total runs over/under set at nine. Mikolas’ over/under for hits allowed stands at 5.5. Before making your picks on the Cardinals vs. Red Sox match-up, it’s wise to refer to predictions from SportsLine’s trusted model.
This model simulates each MLB game 10,000 times and enters the 2025 season on a solid 32-17 winning streak on top-rated run-line bets since 2023. Betting enthusiasts who have followed along with sportsbooks and betting apps could have seen rewarding returns.
Best Bets for Cardinals vs. Red Sox:
- Red Sox to win (-124): Boston is in great form, having outscored opponents 24-13 across the previous three games. The Cardinals have a team ERA of 4.85, ranking them ninth-worst in the MLB. Right fielder Wilyer Abreu is off to a stellar start, batting .500 with two doubles, three home runs, and eight RBIs.
- Over 9 total runs (-115): Each of their last five matchups has seen both teams score at least nine runs. The model projects ten total runs, indicating that the over should hit in more than 50% of simulations.
- Both teams to score three or more runs (-142): Both clubs entered Sunday ranked among the top ten offenses in terms of runs scored. The Cardinals lead the league with a .302 batting average, while the Red Sox hold the sixth spot at .256.
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