The Minnesota Twins are looking to secure a three-game series sweep against the struggling Chicago White Sox on Thursday as the White Sox continue their dismal start to the 2025 MLB season. Minnesota triumphed over Chicago with a score of 6-3 on Wednesday, following a 4-2 victory on Tuesday, bringing their record against the White Sox to 16-2 since the previous season. Currently, the Twins stand at 9-15 for the season while the White Sox have fallen to 5-19.

The first pitch will be at Target Field in Minneapolis, Minn., at 1:10 p.m. ET. In the latest betting odds on FanDuel, Minnesota is favored at -225 (bet $225 to win $100) while Chicago is the underdog at +188. The total runs over/under is set at 8. Before placing any wagers, make sure to check the picks from SportsLine’s reliable MLB predictions model.

SportsLine’s model has run simulations of this matchup 10,000 times and is on a solid 13-6 run for high-stakes MLB picks, meaning there is serious potential for profit for bettors.

Why the White Sox Can Cover

First baseman Andrew Vaughn has been a glimmer of hope for Chicago, hitting a double on Wednesday and providing a necessary power source during their offensive struggles. Despite their challenges, the White Sox will likely regain confidence against Chris Paddack, who they scored nine runs against in their last matchup.

Why the Twins Can Cover

The Twins have been bolstered by outfielder Byron Buxton, who hit his fifth home run of the season in their recent victory. Minnesota has been dominant against Chicago and looks to continue that trend in this game.

Make Your Picks

With projections indicating 9.1 combined runs in this matchup, SportsLine advises taking action on this game for potential winnings. To access SportsLine’s comprehensive picks, visit the website now.