The Chicago Cubs are set to continue their series against the Philadelphia Phillies this Saturday, April 26, 2025. The Cubs celebrated a convincing 4-0 victory in the series opener on Friday. As of now, the Phillies are struggling with a record of 13-13, having lost five consecutive games and only managing a 4-9 record in away games this season. Meanwhile, the Cubs have won three straight games and have a solid 9-5 home record.

First pitch is scheduled for 4:05 p.m. ET, with Philadelphia listed as a -112 favorite according to Fanduel Sportsbook. Additionally, the over/under for this matchup is set at 7 runs. Before making any betting decisions, it’s essential to consult the predictions from SportsLine’s reliable simulation model.

Predictions from the Model

The model has simulated this matchup 10,000 times, with the following bets standing out:

Phillies to win (-110) - In their previous encounters, the Phillies have enjoyed relative success over the Cubs, winning four out of the last six games including a series win at Wrigley last season. Phillies pitcher Jesus Luzardo (2-0, 2.08 ERA) is expected to take the mound, who has been in excellent form throughout the season.

Over 7 total runs (-112) - Historically, these teams often combine for eight or more runs in their encounters, with the Cubs scoring seven or more runs in two of their last three games.

Ben Brown over 5.5 strikeouts (-105) - Cubs pitcher Ben Brown (2-1, 4.57 ERA) is known for consistently hitting strikeouts, averaging at least five in each of his previous outings this season.

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