Monday’s MLB schedule features 11 games, including three interleague and two intradivisional matchups. In a key game, the New York Yankees are road favorites against Seattle according to various sportsbooks, including FanDuel, which lists New York at -134 on the money line. Another significant matchup involves the Arizona Diamondbacks facing the San Francisco Giants, with Arizona favored at -119.
The Washington Nationals head to Atlanta to take on the Braves, where Atlanta is a -230 favorite. Meanwhile, the Milwaukee Brewers visit Cleveland to challenge the Guardians, with Milwaukee at -121.
The model simulates each game 10,000 times and is currently on a 12-8 roll (60%) on top-rated MLB money-line picks for the season. Anyone who followed closely could have seen nice returns.
Top MLB Picks for Monday
Back the Tigers (+103) against the Red Sox
Detroit aims to end a two-game losing streak against the Boston Red Sox. Despite recent losses, the Tigers are 7-3 in their last 10 games. Boston, on the other hand, is 5-5 over their last 10 after winning two straight.
Right-hander Jackson Jobe (2-0, 4.88 ERA) will take the mound for the Tigers, while the Red Sox will send Tanner Houck (0-2, 6.10 ERA). Jobe has surrendered only three earned runs over 10 innings at Comerica Park in 2025. Detroit has won three of the last four meetings against Boston, including two of three games late last season.
DraftKings Sportsbook has the best odds for Detroit at +103 on the money line, and there’s an offer for $200 in bonus bets on a $5 wager.
Go Over 7.5 runs (-112) in Diamondbacks vs. Giants
A high-scoring game is expected at Oracle Park, as both teams are among the league’s top scoring units this season. Arizona ranks fifth with 205 runs in 40 games, while San Francisco is 12th with 185 runs. In their last 10 matchups, the Giants and Diamondbacks have scored eight or more runs eight times.
Other Key Matchups
- Brewers at Guardians: (+102, 8.5)
- Red Sox at Tigers: (+103, 8.5)
- Cardinals at Phillies: (-179, 8.5)
- Pirates at Mets: (-164, 7)
- Nationals at Braves: (-190, 8.5)
- Marlins at Cubs: (-260, 8.5)
- Rockies at Rangers: (-260, 8.5)
- Royals at Astros: (-120, 8)
- Yankees at Mariners: (+124, 8)
- Angels at Padres: (-211, 7)
- Diamondbacks at Giants: (-101, 8)
