The series transitions back to Madison Square Garden as the New York Knicks, seeded third, take on the second-seeded Boston Celtics in Game 6 of the 2025 NBA Eastern Conference semifinals on Friday. The Celtics, facing elimination at a 3-1 deficit, managed to dominate New York 127-102 in Game 5. Jayson Tatum (Achilles) will not be playing for Boston. The game is set for 8 p.m. ET at Madison Square Garden. Currently, the Knicks are slight favorites by 2.5 points, with an over/under set at 209 points according to the latest odds from DraftKings Sportsbook. So far, the Knicks hold a record of 47-45-1 against the spread, while the Celtics are at 43-48-1.

The SportsLine Projection Model simulates each NBA game 10,000 times and has been highly profitable, yielding over $10,000 in profit for $100 bettors on its best NBA picks in the last six seasons. Currently, the model is on a remarkable 159-117 run on all top-rated NBA picks, generating nearly $4,000 in return. It has shown a particularly strong performance this playoff season, achieving a 23-11 (68%) success rate on top-rated NBA against-the-spread picks.

Now, here are the model’s top three player prop bets for the Celtics vs. Knicks game on Friday:

New York Knicks -2.5 (-110)

The Knicks possess a 7-4 record against the spread during the 2025 NBA playoffs and have gone 20-14 against the spread following a defeat. Playing in front of their home crowd, this matchup presents a fantastic opportunity for New York to eliminate their biggest rival and reigning champions. The Knicks’ home record during the regular season was 27-14, and they have secured two of their three wins this series by margins of three points or more.

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Jalen Brunson 30+ Points (-130)

Brunson is crucial to the Knicks’ offensive strategy with his exceptional shooting skills. In the current playoffs, he leads the team with an average of 29.4 points per game and boasts a 36.1% accuracy rate from three-point range. He has scored over 30 points in six out of his last 11 games, and three of those occurred on home turf during this postseason. Expect an aggressive approach from Brunson as the series reaches a potential turning point.

Derrick White 5+ Three-Pointers Made (+115)

White serves as an ideal fit for the Celtics’ offensive style, displaying an ability to thrive off the ball and a quick trigger from long range. He shoots 39.6% from beyond the arc and has hit five or more three-pointers in three instances during this series, including an impressive 7-of-13 performance from three-point range in Game 5. With Tatum sidelined, the Celtics will rely on White to step up and contribute significantly to their offense. New players who haven’t registered with DraftKings yet can claim $200 in instant bets upon staking $5.

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Want more NBA picks for today? You’ve seen the model’s best bets for Friday’s playoffs. Get spread, total, and money-line picks for every game here, all sourced from the simulation model that has run 10,000 iterations per game.

Also available at SportsLine: You can check out today’s top NBA picks from expert Bruce Marshall, who is currently enjoying a successful 129-99-1 streak on his last 230 NBA predictions. Visit SportsLine to discover his optimal strategies for the day, all from the expert who has gained over 20 units.