The Buffalo Bills are distinguished as the sole team expected to win every match in the 2025 NFL season. Even though they are not the defending champions, such as the Philadelphia Eagles or Kansas City Chiefs, they are aiming for an end to their 32-year Super Bowl drought.
The reigning AFC East champions are currently the only team favored in each of their games according to early betting predictions. BetMGM has set the Bills’ total wins at over/under 11.5, indicating that while being favored, they might not achieve an undefeated season, which would place them among only two other teams in league history that have done so.
Despite the odds of an undefeated season being slim—similar to the chances of Tiger Woods winning a major again this year—Buffalo remains the top pick to clinch the AFC East. The roster includes star quarterback Josh Allen and running back James Cook, complemented by enhancements this offseason, including the addition of notable players like Joey Bosa and first-round pick Maxwell Hairston.
Game-by-Game Odds for the 2025 Season
| Week | Date | Opponent | Bills Spread |
|---|---|---|---|
| 1 | Sept. 7 | Baltimore Ravens | -1.5 |
| 2 | Sept. 14 | at New York Jets | -8.5 |
| 3 | Sept. 18 | Miami Dolphins | -8.5 |
| 4 | Sept. 28 | New Orleans Saints | -12.5 |
| 5 | Oct. 5 | New England Patriots | -8.5 |
| 6 | Oct. 13 | at Atlanta Falcons | -5.5 |
| 7 | BYE | ||
| 8 | Oct. 26 | at Carolina Panthers | -7 |
| 9 | Nov. 2 | Kansas City Chiefs | -2.5 |
| 10 | Nov. 9 | at Miami Dolphins | -5.5 |
| 11 | Nov. 16 | Tampa Bay Buccaneers | -5.5 |
| 12 | Nov. 20 | at Houston Texans | -3.5 |
| 13 | No. 30 | at Pittsburgh Steelers | -4.5 |
| 14 | Dec. 7 | Cincinnati Bengals | -5.5 |
| 15 | Dec. 14 | at New England Patriots | -5.5 |
| 16 | Dec. 21 | at Cleveland Browns | -8.5 |
| 17 | Dec. 28 | Philadelphia Eagles | -1.5 |
| 18 | Jan. 4 | New York Jets | -9.5 |
Here’s hoping the Bills can overcome the odds!
