The upcoming game on June 3, 2025, features the Pittsburgh Pirates (22-38) against the Houston Astros (32-27) in a three-game series. The Astros have a recent record of winning two out of their last three matches, including a 1-0 victory over the Tampa Bay Rays. Meanwhile, the Pirates faced a 6-4 defeat against the San Diego Padres on June 1.

Lance McCullers Jr. (0-1, 5.89 ERA) will be pitching for the Astros, while Paul Skenes (4.5, 2.15 ERA) takes the mound for the Pirates. The first pitch is scheduled for 6:40 p.m. ET. In the latest betting odds from FanDuel Sportsbook, Pittsburgh is favored at -159 (bet $159 to win $100), with an over/under total of 7 runs.

Join the action as the SportsLine Projection Model has simulated this matchup 10,000 times, providing accurate predictions for bettors. In the latest trends, Jeremy Pena leads the Astros with a .309 batting average and 69 hits, while Oneil Cruz can significantly impact for the Pirates with his power, leading the team with 12 home runs.

For detailed predictions and insights about who’s likely to win and reasons behind the odds, check respected platforms like SportsLine.