An American League clash will see the Seattle Mariners (48-45) facing the Detroit Tigers (59-35) on Friday evening. Both teams are coming off defeats: Seattle lost 6-5 to the New York Yankees, ending in extra innings after a three-game sweep, while Detroit fell 7-3 to Tampa Bay, breaking their five-game winning streak.
Luis Castillo (5-5, 3.31 ERA) will pitch for the Mariners, while Tarik Skubal (10-2, 2.02 ERA) will represent the Tigers. Notably, Detroit has won five out of the last six games against Seattle.
First pitch at Comerica Park is scheduled for 7:10 p.m. ET, with the Tigers favored at -289 (risking $289 to win $100), while the Mariners are at +231 (risking $100 to win $231). The over/under for total runs scored is 7.
Before locking in your Mariners vs. Tigers picks, take a look at predictions from SportsLine’s proven model.
The SportsLine Projection Model conducts 10,000 simulations for every MLB game. Heading into Week 16 of the 2025 season, it boasts a 45-38 record on top-rated MLB picks and has delivered over 40 units of profit on home run prop picks this season. For more insights, check out the best options provided by sportsbooks, as well as promo codes like BetMGM and FanDuel.
Best Bets for Mariners vs. Tigers
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Randy Arozarena Over 0.5 hits (-142)
Arozarena’s batting average in July stands at .273 with hits in nine of his last twelve games. In his latest match, he recorded one hit from four at-bats. The model projects him to achieve 0.9 hits against Detroit. -
Zach McKinstry Over 0.5 hits (-231)
McKinstry leads his team with a .286 batting average and has surpassed 0.5 hits in nine of his last fifteen games. He was 2-of-4 with two doubles in his last game. In a prior series against Seattle, he hit in two of three matches. -
Tarik Skubal Under 8.5 strikeouts (+104)
Skubal ranks among the top pitchers in the league with a 2.02 ERA and 148 strikeouts. However, he has not exceeded 8.5 strikeouts in five of his last seven outings. The model estimates he will deliver 7.2 strikeouts in this matchup.
