The American League aims for back-to-back wins and 11 in the last 12 against the National League in the 2025 MLB All-Star Game on Tuesday. Last year, the AL secured a 5-3 victory, breaking a nine-game NL losing streak in 2023. Historically, the AL leads the all-time series with a record of 48-44-2, having outscored the NL 388-380 over 94 games.
Paul Skenes (4-8, 2.01 ERA) is set to pitch for the NL, while Tarik Skubal (10-3, 2.23 ERA) will take the mound for the AL. Shohei Ohtani is favored at +550 for the All-Star Game MVP, followed by Aaron Judge at +600.
The first pitch is scheduled for 8 p.m. ET from Truist Park, marking Atlanta’s third time hosting the Midsummer Classic. Since 1997, the AL has dominated with a 22-4-1 record. Currently, the NL is seen as a -132 money line favorite (bet $132 to win $100) in the latest odds, while the over/under is set at 7 runs.
Before finalizing your picks for this matchup, check out the predictions from SportsLine’s Matthew Severance, who boasts an impressive 182-110-1 record in his last 293 MLB predictions, netting over $1,000 in profits.
The odds for the game are:
| Matchup | Odds |
|---|---|
| American League vs. National League Money Line | American League +108, National League -132 at DraftKings |
| American League vs. National League Over/Under | 7 runs |
| American League vs. National League Run Line | American League -1.5 (+177) |
