Mario Barrios will aim to defend his WBC welterweight title against former champion Manny Pacquiao in a scheduled 12-round bout on Saturday. The fight will commence around 8 p.m. ET at the MGM Grand Garden Arena in Las Vegas. Barrios comes off a recent 12-round draw with Abel Ramos last November. Pacquiao, on the other hand, will step back into the ring for the first time in nearly four years following his unanimous decision loss to Yordenis Ugas for the WBA welterweight title on August 21, 2021.

Barrios is favored at -275 (meaning you would need to wager $275 to win $100), while Pacquiao is at +210. The total rounds are projected at 10.5, with over bets favored at -140. Make sure to check out Josh Nagel’s boxing predictions for more insights.

Nagel has been following this fight from all angles and will share his top picks and best bets.

Why You Should Support Barrios

Barrios, 30, has held the WBC welterweight title since 2024, winning it following a unanimous decision over Ugas on September 30, 2023. With a professional record of 29 wins and 2 losses, and having secured 18 knockouts, Barrios remains a formidable opponent. His only defeats came from Gervonta Davis in June 2021 and Keith Thurman in February 2022.

Why You Should Support Pacquiao

Manny Pacquiao, famously known as Pac Man, is a unique boxer, having claimed 12 world championships across eight separate weight classes. Recently, he was inducted into the International Boxing Hall of Fame, marking a significant milestone in his storied career. With a professional record of 62 wins and 8 losses, he has 39 wins by knockout.

How to Make Your Picks

Nagel suggests backing the Over 9.5 total rounds, along with a strong money-line pick and a method-of-victory prop that promises good returns. Check out SportsLine for all the details.