This weekend promises to be exciting for boxing fans with three significant events scheduled on Saturday. The cards feature title fights and prominent names, including Oleksandr Usyk vs. Daniel Dubois for the undisputed heavyweight championship and Manny Pacquiao returning from retirement at age 46 to face Mario Barrios for the WBC welterweight title.

Usyk aims to become the undisputed heavyweight champion for the second time after being stripped of the IBF title following his win over Tyson Fury. Meanwhile, Pacquiao’s inactivity since his 2021 defeat to Yordenis Ugas raises concerns as he faces a younger opponent in Barrios.

With various fights on the cards, betting interest is sure to flourish across numerous sportsbooks. Here’s a guide on our betting picks, maintaining a successful record of 9-2 on boxing bets for 2025. Our recommendations are odds of -250 or better.

Oleksandr Usyk vs. Daniel Dubois

Usyk via decision (+170)
The consensus is that this fight may not go the distance; however, I foresee it lasting the full 12 rounds as both opponents are well aware of each other’s capabilities. Usyk is the superior boxer and is likely to win on points.

Mario Barrios vs. Manny Pacquiao

Barrios via KO/TKO/DQ (+135)
A Pacquiao victory would be a remarkable story. Nonetheless, at 46, returning from a lengthy hiatus against a well-prepared and active Barrios poses a considerable challenge for him. Expect Barrios to impose himself as the fight progresses.

Sebastian Fundora vs. Tim Tszyu

Tim Tszyu moneyline (-155)
This matchup on the undercard could be thrilling. Fundora edged out Tszyu in their previous clash, but Tszyu showed promise and could turn the tables this time.

Jesse Rodriguez vs. Phumelela Cafu

Under 7.5 rounds (-115)
Rodriguez enters this fight as a heavy favorite and is expected to dominate, making the under 7.5 rounds the best available bet here.