The reigning Super Bowl champion Philadelphia Eagles are set to kick off their title defense against their biggest rivals, the Dallas Cowboys, during the 2025 NFL kickoff game on Thursday, September 4. Philadelphia convincingly defeated the Kansas City Chiefs with a score of 40-22 to clinch Super Bowl LIX last February. The Cowboys, who struggled with a 7-10 record in 2024, sparked significant attention on August 28 by trading Micah Parsons to the Green Bay Packers. Looking to rebound after finishing first in the division in 2023, the Cowboys recorded a 12-5 performance. The Eagles, with a 14-3 record in 2024, aim to repeat as division champions, a feat last achieved by them between 2001 and 2004.

Kickoff will take place at 8:20 PM ET at Lincoln Financial Field in Philadelphia. Historically, the Cowboys lead the all-time series against the Eagles with a record of 74-58, including nine victories in their last 15 encounters. Currently, Philadelphia is favored by 7.5 points, and the total points over/under is set at 47.5.

Before finalizing any bets on the Cowboys vs. Eagles matchup, it’s crucial to consider Matthew Severance’s expert predictions. For instance, he has profited significantly from his recent betting decisions, showcasing an impressive 37-12 record. His insights are essential for anyone looking to make informed bets on this iconic matchup.

In terms of individual performance, Jalen Hurts, the Eagles’ quarterback, recorded a 68.7% completion rate with 2,903 yards and 18 touchdowns, alongside 5 interceptions in the past season. On the other hand, Dak Prescott is coming off a season where he played through injuries, registering 1,978 yards and 11 touchdowns, with a completion percentage of 64.7%. Each quarterback’s performance could indeed prove decisive in determining the outcome of this thrilling matchup.

To summarize, as the rivalry heats up, be sure to keep an eye on player performance, historical stats, and expert betting insights to make the most informed predictions possible.