The NFL preseason has concluded, and attention now shifts to Week 1 of the NFL schedule, which is just around the corner. The action kicks off with a matchup between the Cowboys and Eagles in the 2025 NFL Kickoff Game on Thursday, followed by the Chiefs facing the Chargers in Brazil on Friday. Sunday features thirteen games, culminating with the Vikings against the Bears on Monday.

NFL bettors are focused on spreads, totals, and money-line predictions. Key week 1 odds to watch include the Eagles at -7.5 versus the Cowboys, a shift since the Micah Parsons trade, and the Vikings at -1.5 against the Bears. Meanwhile, the Bills are favored at -1.5 over the Ravens in a notable Sunday Night Football clash.

Expert Eric Cohen has provided precise predictions for Week 1 NFL scores that can enhance your betting strategy for each game while offering insights on profitable NFL props. Achieving an accurate score could lead to considerable winnings!

Cohen showcases his analysis for all 16 Week 1 NFL games, sharing score predictions and reasoning for each contest. Notably, he concluded the 2024-25 season with an impressive record of 190-95 on straight-up NFL selections (69%) and has proven beneficial for bettors. Those who followed Cohen’s predictions have enjoyed success at their preferred sports betting platforms.

‘In my view, these are the two top teams in the NFL, and we’re likely to see this rematch again on January 25th, 2026, in the AFC Championship Game.’
Translation: Cohen views the matchup as critical for determining playoff standings.

Be sure to check out the complete set of his NFL Week 1 score predictions exclusively at SportsLine!