The Week 1 NFL schedule kicks off with a thrilling matchup: the Cowboys will face the Eagles in the opening game of the 2025 season. Following this, the Chiefs will take on the Chargers in Brazil on Friday. Sunday marks a jam-packed day with thirteen games, culminating with the Vikings battling the Bears on Monday night.

Veteran NFL bettors are focusing on the spreads, totals, and money-line picks this week. Some notable odds include the Eagles favored by -7.5 against the Cowboys, reflecting a shift after the recent Micah Parsons trade, and the Steelers at -2.5 vs. the Jets. Additionally, the Bills are slightly favored at -1.5 over the Ravens, engaging in a highly anticipated Sunday Night Football clash.

For detailed score predictions and insights, check out Eric Cohen’s Week 1 score forecast.

Cohen has established a strong record in predicting NFL outcomes, with a 190-95 finish last season on straight-up picks (at a notable 69% success rate). Following his predictions often translates to profit for sports betting enthusiasts.

In his analysis, Cohen is expecting a thrilling rematch between the Bills and Ravens with a predicted final score of 26-23 in favor of Buffalo, ranking these teams as the top contenders in the league.

“In my perspective, these are the two best teams in the NFL, and a rematch is likely on the horizon for the AFC Championship Game in 2026,” he commented.

For all score predictions and betting recommendations, visit SportsLine.