The 2025 NFL season kicks off on Thursday with the Philadelphia Eagles hosting the Dallas Cowboys in the opening game. Week 1 spans from Thursday to Monday, including an international game in São Paulo between the Kansas City Chiefs and Los Angeles Chargers, as well as a Sunday Night showdown with the Baltimore Ravens facing the Buffalo Bills.

To prepare for the games, you should refer to the predictions made by the SportsLine computer simulation model, which has shown substantial profits for bettors. The model evaluates each matchup and has provided analysis for bettor’s consideration.

Top Week 1 NFL simulation picks:

The simulation predicts the Washington Commanders to cover against the New York Giants, aiming for a successful season after their impressive run to the NFC Championship Game last year. The Commanders’ young quarterback, Jayden Daniels, is expected to lead a potent offense bolstered by All-Pro Deebo Samuel.

You can find the full details of these predictions along with expert recommendations at SportsLine, where you can also take advantage of exclusive betting promotions like the DraftKings promo code.