The 2025 NFL season kicks off this Sunday, and while traditional wagers like spreads and totals are available, numerous longshot opportunities are also up for grabs across various sportsbooks. Higher odds come with increased risk, but they also promise larger payouts. According to the SportsLine model, several longshot bets featuring key NFL players exhibit significant potential value for Week 1.
One of the top recommendations is for Kyler Murray from the Cardinals to surpass 260 passing yards, with odds at DraftKings set at +234 (bet $100 to win $234). Murray’s passing yard line is set at 222.5, but our model highlights the more favorable odds at 260+.
Best Week 1 Longshot Picks
- Giants vs. Commanders Over 52.5 points (+210)
- Bo Nix, Broncos, 250+ passing yards (+225)
- Kyler Murray, Cardinals, 260+ passing yards (+234)
For those interested in Week 1 projections and bets, the SportsLine model consistently demonstrates its worth, having shown significant profits since its launch.
