SEC rivals will clash in Week 2 as the Kentucky Wildcats welcome the No. 20 Ole Miss Rebels. In their previous encounter in Week 5 last season, Kentucky managed to secure a close 20-17 win. Both teams kicked off their 2025 campaigns successfully, with Ole Miss decisively defeating Georgia State 63-7, while Kentucky pulled through against Toledo with a 24-16 scoreline.

Kickoff for the match at Kroger Field in Lexington is scheduled for 3:30 p.m. ET. According to the latest odds from SportsLine, the Rebels are favored by 9.5 points, and the over/under for total points is placed at 50. Prior to making any predictions for the Kentucky vs. Ole Miss game, it’s crucial to review the insights from the SportsLine projection model.

The model has simulated this matchup 10,000 times. Historically, it has provided a betting profit exceeding $2,000 for $100 players based on top-rated college spread picks and produced a respectable 27-16 record on money-line and over/under selections last season, making it a reliable source for betting advice.

Key Predictions from SportsLine for the Upcoming Match:

• Ole Miss -9.5
• Under 50

Ole Miss -9.5

Ole Miss has been dominant in this rivalry, winning the last three matchups before last season’s game, and they are likely eager to reclaim their advantage. Quarterback Austin Simmons will face greater challenges this week but has shown capability, throwing for 341 yards and three touchdowns in the opener. Defensively, Kentucky will need to step up after a lackluster passing performance from Zach Calzada.

Under 50

The under has hit in eight Kentucky games along with ten Ole Miss contests last year. Ole Miss’ defense was the best in the SEC, allowing an average of just 14.4 points per game last season, instilling confidence following their last match where they permitted only one touchdown.

For further predictions on this week’s matchups, consult SportsLine for complete against the spread, total, and money-line predictions.