The Seattle Seahawks will kick off their 2025 season by hosting an NFC West showdown against the San Francisco 49ers this Sunday. Having finished the previous season with a record of 10-7 but just missing the playoffs under coach Mike Macdonald, the Seahawks look to bounce back. In contrast, the 49ers, who had a disappointing 6-11 season after their Super Bowl run last year, aim to flip the script.
A notable aspect of Sunday’s matchup is the potential return of star running back Christian McCaffrey for the 49ers, alongside Sam Darnold’s debut for Seattle as their quarterback. In recent history, San Francisco has dominated, winning six out of their last seven encounters despite losing the last one 20-17 last November.
Kickoff is set for 4:05 PM ET at Lumen Field in Seattle. The latest betting lines from SportsLine show the 49ers as 1.5-point favorites, with an over/under total of 43 points. The betting suggests the 49ers have slightly better odds at -128 money line favorites compared to the Seahawks at +109.
Key Predictions from SportsLine:
- Seahawks +1.5: The Seahawks’ performance as home underdogs last season was shaky, but players like Kenneth Walker III and Zach Charbonnet are crucial assets. Darnold, after a solid season with the Vikings, has a strong supporting team that could take advantage of the 49ers’ weakened receiving corps.
- Over 43: Historically, both teams have favored higher-scoring games. Recent matchups indicate a tendency to exceed this total.
For complete NFL betting advice and expert picks, review the options available at SportsLine.
