The Buffalo Bills seek to maintain their unbeaten streak and take control of the AFC East as they face the New England Patriots during Sunday Night Football. Buffalo recently secured a victory against the New Orleans Saints with a score of 31-19, while New England triumphed with a dominant 42-13 win over the Carolina Panthers in Week 4.
The Patriots (2-2), who remain undefeated within the division and are also 1-0 on the road in 2025, will take on the Bills (4-0), who boast a 2-0 division record and are unbeaten at home. Buffalo has historically performed well at home against the Patriots, winning the last four matchups.
Kickoff is scheduled for 8:20 PM ET at Highmark Stadium in Orchard Park, NY. The Patriots lead the all-time series 79-51-1, but the Bills have emerged victorious in eight of the last eleven encounters. The consensus odds from SportsLine show Buffalo favored by 7.5 points, with a total points over/under line of 49.5, marking it the highest for Week 5. Buffalo is a -429 favorite on the money line (risk $429 to win $100) while New England stands at +334 (risking $100 to win $334).
Before placing any bets, make sure to check out sports expert Mike Tierney’s insights.
Why the Bills are Likely to Win
Quarterback Josh Allen, last year’s NFL MVP, has had an impressive season. So far, he has completed 85 of 121 passes (70.2%) for 964 yards with seven touchdowns and only one interception in four games, alongside rushing 31 times for 159 yards and three touchdowns. He delivered a strong performance against the Baltimore Ravens, completing 33 of 46 passes for 394 yards and two touchdowns.
Running back James Cook has been a vital part of their offensive strategy, averaging 5.3 yards per carry with five touchdowns in four games. In the last match against New Orleans, he gained 117 yards on 22 carries.
Why the Patriots May Succeed
Quarterback Drake Maye is having a stellar start, completing 91 of 123 passes (74%) for 988 yards and seven touchdowns in four games. In the previous game against the Panthers, he threw for 203 yards and two touchdowns, showcasing his strong capability on the field.
His top target is wide receiver Stefon Diggs, who has tallied 19 receptions and 213 yards this season, notably catching six passes for 101 yards against Carolina.
To make the best bets, Tierney has analyzed every angle of this matchup, leaning towards a point total below the average. His detailed predictions are available on SportsLine.
