NFL DFS: Optimizer Reveals Ideal Strategy for Week 10 of 2025
Ten more NFL games are set for Sunday afternoon at either 1 p.m. ET or 4:05/4:25 p.m. ET, forming the primary slate for NFL daily fantasy sites like FanDuel and DraftKings. Notably, the Bills vs. Dolphins matchup has the highest over/under for the week at 50, making it a focus for daily fantasy players featuring prominent athletes including Josh Allen, De’Von Achane, and James Cook. Other significant players include Lamar Jackson, Justin Jefferson, Breece Hall, and Kyren Williams.
How should these players influence your NFL DFS selections, and who are the standout sleeper picks that can elevate your lineups? Be sure to check out SportsLine’s advanced NFL DFS lineup optimizer before finalizing your lineups this Sunday.
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The optimizer utilizes information from the SportsLine Advanced-Data Projection Model alongside DFS seasoned Millionaire Mike McClure to pinpoint top DFS picks for any slate on betting platforms such as DraftKings and FanDuel. This tool simulates each game 10,000 times, assisting DFS players in optimizing and constructing winning lineups.
Now, SportsLine’s optimizer has set its sights on the NFL Week 10 schedule for 2025 and has locked in its premier daily fantasy football lineups. You can exclusively view the optimal lineups at SportsLine.
Top NFL Week 10 DFS picks for Sunday The optimizer highlights Jared Goff, quarterback for the Detroit Lions, as a key value pick at $5,900 on DraftKings and $7,800 on FanDuel. Goff averages nearly 240 passing yards weekly, with only one outing below 200 yards this season, which establishes a high floor for his performance. He’s also thrown 17 touchdowns against merely three interceptions. His team is facing the Washington Commanders, known for conceding the fifth-most Fantasy points to rival quarterbacks.
The NFL DFS optimizer suggests also focusing on Rico Dowdle, running back for the Carolina Panthers, priced at $8,000 on FanDuel and $6,300 on DraftKings. Since assuming the starting role in Week 5, Dowdle has excelled, accruing 652 rushing yards and three touchdowns, complemented by ten receptions and a receiving touchdown. He’ll compete against the New Orleans Saints, who rank 22nd in points allowed to opposing running backs.
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The optimizer is also focusing on various undervalued players with the potential for substantial performances this Sunday. These athletes may differentiate your results in tournaments and cash games. You can view the full list of these players, as well as the optimizer’s additional NFL DFS selections, at SportsLine.
