The Old Dominion Monarchs will compete against the South Florida Bulls in the upcoming 2025 Cure Bowl on Wednesday. Both teams have shown strong performances this season with Old Dominion finishing with five straight victories while USF secured three of their last four games. The Monarchs (9-3) are coming off a solid second place position in the Sun Belt East Division with a scoring differential of 161 points. Meanwhile, the Bulls (9-3), who are tied for fourth in the American Conference, boasted a scoring margin of 236 points.

Notably, both starting quarterbacks, Byrum Brown from USF and Colton Joseph from Old Dominion, will not play in the game. Additionally, Coach Alex Golesh along with most of his offensive coaching staff will miss the game since he accepted a position with Auburn.

Kickoff is scheduled for 5 p.m. ET at Camping World Stadium in Orlando, Florida. According to current odds, the Bulls are 4-point favorites with a total points expectation set at 52.5.

Prior to making any predictions on the matchup, check the SportsLine for insights and expert forecasts.

Matchup	Spread
Old Dominion vs. South Florida	USF -4 at DraftKings Sportsbook
Over/Under	52.5 points
Money Line	USF -191, Old Dominion +159

This predictive model utilizes extensive simulations to provide data-driven insights for each game. It has highlighted that Old Dominion running back Trequan Jones is expected to rush for over 80 yards and score, while USF’s running backs – including Nykahi Davenport, Sam Franklin, and Alvon Isaac – are projected to collectively rush for over 100 yards. Ultimately, the total points are forecasted to exceed 56.

For detailed betting insights and other predictions for Old Dominion vs. South Florida, visit SportsLine.

Summary of Predictions:

• Expect a high-scoring game with strong offensive plays from both teams.
• Analyze odds carefully before making any bets.