For the first time since 2020, Real Madrid suffered a defeat to Real Betis, with notable performances from American midfielder Johnny Cardoso and former Real Madrid player Isco. Despite this setback in the La Liga title race, Madrid remains optimistic as they focus on Champions League commitments.

When they face Atletico Madrid on Tuesday, several players who participated in this match may not be in Carlo Ancelotti’s starting lineup. Injuries could see key figures like Fede Valverde omitted, raising questions about their strategy. Nevertheless, the hope is that they can still contend for both trophies.

Cardoso opened the scoring against Madrid, marking a significant moment in his career with Betis. He achieved this through a header assisted by Isco’s corner kick, which was his first goal of the season.

JOHNNY CARDOSO BRINGS BETIS LEVEL AGAINST MADRID 🇺🇸 HIS FIRST OF THE SEASON IN LALIGA! pic.twitter.com/mXJoLbpnsu — ESPN FC (@ESPNFC) March 1, 2025

Isco played a pivotal role for Betis, netting a penalty that established their lead in the second half, stemming emotions high due to his past with the club. His performance this season has been impressive, contributing significantly in both goals and assists.

Although the loss is concerning for Real Madrid, it does not define their season. As long as Ancelotti maintains his strategy effectively, there remain ample opportunities ahead. Their performance in the upcoming round of 16 will be crucial in determining their outlook for both La Liga and Champions League progression.