The 2025 MLB season continues on Friday with a nine-game slate following an exciting Opening Day. San Diego erased a 4-3 deficit in its 7-4 win over Atlanta, as Manny Machado drove in a run during a four-run seventh inning for the Padres. Machado is listed at +170 (risk $100 to win $170) to record an RBI when the teams meet again on Friday night, according to the latest MLB odds from BetMGM.

There are plenty of other MLB player props and MLB same-game parlays to consider at the top sportsbooks, and SportsLine’s proven computer model can help inform your MLB best bets.

The model simulates every game 10,000 times and is on a 32-17 roll on all top-rated MLB picks on the run line dating back to 2023. Now, the model and SportsLine’s team of Data Scientists have revealed their projections for some of the most-bet MLB player props on Friday.